In this whitepaper, the authors briefly describe the three major MOEs, followed by a categorization summary based on the most recent literature. Next, a number of typical CAV applications have been examined in depth, providing a detailed analysis of the different MOEs co-benefits and tradeoffs. Further, three representative CAV applications have been examined in detail in order to show the association between the application focus and tradeoffs/co-benefits of different performance measures. The CAV applications include High Speed Differential Warning (safety-focused), Lane Speed Monitoring (mobility-focused), and Eco-Speed Harmonization (environmental impacts-focused). The authors then highlight several future research directions, including the identification of key influential factors on system performance and how to obtain co-benefits across all key MOEs. The overall intent of this whitepaper is to inform practitioners and policy makers on the potential interactions between the safety, mobility, and environmental sustainability goals of implementing specific CAV applications as part of their ITS programs.